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KMID : 0191120110260070927
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Journal of Korean Medical Science
2011 Volume.26 No. 7 p.927 ~ p.931
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Serum Kisspeptin Levels in Korean Girls with Central Precocious Puberty
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Rhie Young-Jun
Lee Kee-Hyoung
Eun So-Hee
Choi Byung-Min
Chae Hyun-Wook
Kwon Ah-Reum
Lee Woo-Jung
Kim Jung-Hyun
Kim Ho-Seong
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Abstract
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Central precocious puberty (CPP) is caused by premature activation of hypothalamic gonadotropin-releasing hormone (GnRH) secretion. Kisspeptin and G-protein coupled receptor-54 system is the essential gatekeeper of the reproductive system, playing a key role in the activation of the gonadotropic axis at puberty. We aimed to determine whether serum kisspeptin may function as a marker for CPP by investigating serum kisspeptin levels in Korean girls with CPP and their prepubertal controls. Serum kisspeptin levels of Korean girls with CPP (n = 30) and age-matched healthy prepubertal controls (n = 30) were measured with a competitive enzyme immunoassay. Serum kisspeptin levels were significantly higher in CPP group than in control group (4.61 ± 1.78 vs 2.15 ± 1.52 pM/L, P < 0.001). Serum kisspeptin was positively correlated with peak luteinizing hormone (LH), peak/basal LH ratio and peak LH/follicular-stimulating hormone (FSH) ratio during GnRH stimulation test. CPP is supposed to be triggered by premature increase of kisspeptin. Serum kisspeptin may be used as a marker of CPP. Further studies on KISS1 gene polymorphisms leading to higher risk of premature increase of kisspeptin and upstream regulator of kisspeptin are also needed.
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KEYWORD
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Kisspeptin, KISS1 Gene, G-protein Coupled Receptor-54, Central Precocious Puberty, Gonadotropin-Releasing Hormone
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